Browsing by Author "Berger, N. Daniel"

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    Analgesic effect of a mixed T-type channel inhibitor/CB2 receptor agonist
    (BioMed Central Ltd., 2013-07-01) You, Haitao; Gadotti, Vinícius Maria; Petrov, Ravil R.; Berger, N. Daniel; Diaz, Philippe J.; Zamponi, Gerald W.
    Cannabinoid receptors and T-type calcium channels are potential targets for treating pain. Here we report on the design, synthesis and analgesic properties of a new mixed cannabinoid/T-type channel ligand, NMP-181.
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    Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain
    (BioMed Central Ltd., 2015-12) Gadotti, Vinícius Maria; Caballero, Agustin Garcia; Berger, N. Daniel; Gladding, Clare M.; Chen, Lina; Pfeifer, Tom A.; Zamponi, Gerald W.
    Cav3.2 channels facilitate nociceptive transmission and are upregulated in DRG neurons in response to nerve injury or peripheral inflammation. We reported that this enhancement of Cav3.2 currents in afferent neurons is mediated by deubiquitination of the channels by the deubiquitinase USP5, and that disrupting USP5/Cav3.2 channel interactions protected from inflammatory and neuropathic pain.