Browsing by Author "Chen, Tong"
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- ItemOpen AccessCyclodextrin Chemistry: Synthesis of Amphiphilic Fluorescent Glycodendrimers and Development of Acid-mediated O-desilylation Methodology(2015-09-17) Chen, Tong; Ling, Chang-ChunCyclodextrins (CDs) constitute a group of D-glucose-based host molecules with a hydrophobic cavity that can be used to form inclusion complexes with organic compounds. The Ling group has developed a group of amphiphilic glycodendrimers which have been shown to self-assemble into nanoparticles in water, and such systems have been confirmed to deliver anticancer medicines into cancer cells. To further study the cellular uptake mechanism, the present thesis work concerns the design and synthesis of a class of amphiphilic CD-based glycodendrimers containing a fluorophore. NBD was chosen as the fluorophore because it is small and non-ionic. The DIBAL-H reagent allowed a two-fold differentiation of primary hydroxyl groups of the CD molecules, which facilitated the sequential addition of NBD and of sugar moieties. A novel acid-catalyzed O-desilylation methodology has also been developed from this thesis work using the easily accessible per-3,6-O-silylated CD substrates in a mixture of methanol-chloroform.
- ItemOpen AccessKnowledge base creation and managment for automation of the goal-oriented software measurement using multi-agent technology(2004) Chen, Tong; Far, Behrouz Homayoun; Wang, YingxuEffective implementation of a software measurement system to map collected data to business goals in a software organization is a prime problem. Goal Question Metrics (GQM) measurement provides the guidelines to solve this problem. Nevertheless, the GQM approach is complex, knowledge-intensive, iterative, time consuming and therefore expensive. In this thesis, the procedure of automating a specific GQM process has been devised, and the adopted methodologies and technologies also have been introduced. An agent-based system called Intelligent Software Measurement System (ISMS) has been proposed to automatically produce a software measurement implementation plan based on users' initial business or measurement goal(s). As the main part of this research, particularly, a step-by-step methodology for building the knowledge base that is composed of a series of relational tables, weights and factual rules for the ISMS has been presented. In this knowledge base, the various opinions of software measurement experts have been combined and integrated following a specific mathematical theory, Dempster-Shafer theory of evidence. This research could provide a methodology to build a knowledge base for the automation of the GQM process, and make contributions to the design and implementation of intelligent goal-oriented software measurement systems.