Browsing by Author "Koetzler, Rommy"
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- ItemOpen AccessDevelopment and application of an electronic synoptic report for reporting and management of low-dose computed tomography lung cancer screening examination(2022-06-11) Tremblay, Alain; Ezer, Nicole; Burrowes, Paul; MacGregor, John H.; Lee, Andrew; Armstrong, Gavin A.; Pereira, Raoul; Bristow, Michael; Taylor, Jana L.; MacEachern, Paul; Taghizadeh, Niloofar; Koetzler, Rommy; Bedard, EricAbstract Background Interpretation of Low Dose CT scans and protocol driven management of findings is a key aspect of lung cancer screening program performance. Reliable and reproducible methods are needed to communicate radiologists’ interpretation to the screening program or clinicians driving management decision. Methods We performed an audit of a subset of dictated reports from the PANCAN study to assess for omissions. We developed an electronic synoptic reporting tool for radiologists embedded in a clinical documentation system software. The tool was then used for reporting as part of the Alberta Lung Cancer Screening Study and McGill University Health Centre Pilot Lung Cancer Screening Program. Results Fifty reports were audited for completeness. At least one omission was noted in 30 (70%) of reports, with a major omission (missing lobe, size, type of nodule in report or actionable incidental finding in recommendation section of report) in 24 (48%). Details of the reporting template and functionality such as automated nodule cancer risk assessment, Lung-RADS category assignment, auto-generated narrative type report as well as personalize participant results letter is provided. A description of the system’s performance in its application in 2815 CT reports is then summarized. Conclusions We found that narrative type radiologist reports for lung cancer screening CT examinations frequently lacked specific discrete data elements required for management. We demonstrate the successful implementation of a radiology synoptic reporting system for use in lung cancer screening, and the use of this information to drive program management and communications.
- ItemOpen AccessSurfactant and bronchial response(2003) Koetzler, Rommy; Green, FrancisA variety of clinical and experimental evidence indicates that surfactant may be important in the pathogenesis and treatment of asthma. The purpose of this study was to determine the effect of pulmonary surfactant and/or its components on precontracted rat bronchi. Left and right first generation bronchial tissues from male Sprague-Dawley rats were used in the studies done in vitro. Precontracted tissues were exposed to three kinds of surfactant: natural rat surfactant (NRS), bovine lipid extract surfactant (BLES), and Survanta. Surfactant was shown to relax rat bronchi in a concentration-dependent manner. The mechanism of surfactant-induced relaxation was determined. The surfactant relaxation response was inhibited when tissues were devoid of epithelium or when they were treated with indomethacin. N-co-nitro-L-arginine methyl ester (L-NAME) did not affect the surfactant-induced relaxation. Surfactant lipids, unsaturated phosphatidyicholine (uPC), dipalmitoylphosphatidylcholine (DPPC), and phosphatidyiglycerol (PG), and surfactant-specific protein A (SP-A) also showed a relaxant effect whereas non-surfactant lipids and proteins did not. We conclude that surfactant is an airway smooth muscle relaxant. The effect is specific and is dependent on the presence of epithelium and release of prostanoids, but is not dependent on the nitric oxide (NO) pathway.
- ItemOpen AccessThe effects of nitric oxide of human rhinovirus-induced cxcl10 production in airway epithelial cells(2009) Koetzler, Rommy; Proud, David