Please use this identifier to cite or link to this item: http://hdl.handle.net/1880/43436
Title: Control of the proliferation versus meiotic development decision in the C. elegansgermline through regulation of GLD-1 protein accumulation
Authors: Hansen, Dave D.
Wilson-Berry, Laura
Dang,Thanh
Schedl, Tim
Keywords: Biology
Issue Date: 2003
Publisher: The Company of Biologists 2004
Citation: Dave Hansen, Laura Wilson-Berry, Thanh Dang and Tim Schedl "Control of the proliferation versus meiotic development decision in the C. elegansgermline through regulation of GLD-1 protein accumulation " Development 131, 93-104
Abstract: Maintenance of the stem cell population in the C. elegans germline requires GLP-1/Notch signaling. We show that this signaling inhibits the accumulation of the RNA binding protein GLD-1. In a genetic screen to identify other genes involved in regulating GLD-1 activity, we identified mutations in the nos-3 gene, the protein product of which is similar to the Drosophila translational regulator Nanos. Our data demonstrate that nos-3 promotes GLD-1 accumulation redundantly with gld-2, and that nos-3 functions genetically downstream or parallel to fbf, an inhibitor of GLD-1 translation. We show that the GLD-1 accumulation pattern is important in controlling the proliferation versus meiotic development decision, with low GLD-1 levels allowing proliferation and increased levels promoting meiotic entry.
URI: http://hdl.handle.net/1880/43436
ISSN: 0828-0584
Appears in Collections:Hansen, Dave D.

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