Please use this identifier to cite or link to this item: http://hdl.handle.net/1880/51149
Title: Evolution of group II introns
Authors: Zimmerly, Steven
Semper, Cameron
Keywords: Ribozyme;Retroelement;Spliceosome;Molecular evolution;Mobile DNA
Issue Date: 2015
Publisher: BioMed Central
Citation: Zimmerly, S., & Semper, C. (2015). Evolution of group II introns. Mobile DNA, 6(1), 7.
Abstract: Present in the genomes of bacteria and eukaryotic organelles, group II introns are an ancient class of ribozymes and retroelements that are believed to have been the ancestors of nuclear pre-mRNA introns. Despite long-standing speculation, there is limited understanding about the actual pathway by which group II introns evolved into eukaryotic introns. In this review, we focus on the evolution of group II introns themselves. We describe the different forms of group II introns known to exist in nature and then address how these forms may have evolved to give rise to spliceosomal introns and other genetic elements. Finally, we summarize the structural and biochemical parallels between group II introns and the spliceosome, including recent data that strongly support their hypothesized evolutionary relationship.
URI: http://hdl.handle.net/1880/51149
Appears in Collections:Zimmerly, Steven

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