A Population-Based Longitudinal Community Study of Major Depression and Migraine

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dc.contributor.authorModgill Geng
dc.contributor.authorJette N, Wang JL, Becker WJ, Patten SBeng
dc.date.accessioned2012-06-24T19:33:49Z
dc.date.available2012-06-24T19:33:49Z
dc.date.issued2012
dc.descriptionThis "final revision" draft of the paper is archived here in order to meet the requirements of the funding agency.eng
dc.description.abstractObjective: To examine whether major depressive episodes (MDE) are associated with an increased risk of migraine in the general population and to examine whether migraine is associated with an increase risk of MDE. Background: Population-based cross-sectional studies have consistently reported an association between migraine and depression. However, longitudinal studies about this potentially bidirectional association are inconsistent. Methods: This retrospective cohort study used 12 years of follow-up data from the Canadian National Population Health Survey (15,254 respondents, age >12). Stratified analysis, logistic regression, and proportional hazard modeling were used to quantify the effect of migraine on subsequent MDE status and vice versa. Results: After adjusting for sex, age, and other chronic health conditions, respondents with migraine were 60% more likely (HR 1.6, 95% CI 1.3-1.9) to develop MDE compared to those without migraine. Similarly adjusting for sex and age, respondents with MDE were 40% more likely (HR 1.4, 95% CI 1.0-1.9) to develop migraine compared to those without MDE. However, the latter association disappeared after adjustment for stress and childhood trauma. Conclusions: The current study provides substantial evidence that migraine is associated with the later development of major depressive episodes, but does not provide strong causal evidence of an association in the other direction. Environmental factors such as childhood trauma and stress may shape the expression of this bidirectional relationship, however, the precise underlying mechanisms are not yet known.eng
dc.description.grantingagencyCIHReng
dc.description.refereedYeseng
dc.description.sponsorshipCanadian Institutes of Health Researcheng
dc.identifier.citationModgill G, Jette N, Wang JL, Becker WJ, Patten SB. A Population-Based Longitudinal Community Study of Major Depression and Migraine. Headache 2012; 52: 422-432.eng
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33819
dc.identifier.grantnumberMOP-89816eng
dc.identifier.issn1526-4610
dc.identifier.urihttp://hdl.handle.net/1880/49058
dc.language.isoengeng
dc.publisherWiley-Blackwelleng
dc.publisher.corporateUniversity of Calgaryeng
dc.publisher.facultyMedicineeng
dc.publisher.urlhttp://www.headachejournal.org/view/0/index.htmleng
dc.subjectHealth Scienceseng
dc.subjectmigraineeng
dc.subject.otherdepressioneng
dc.subject.othercomorbidityeng
dc.titleA Population-Based Longitudinal Community Study of Major Depression and Migraineeng
dc.typejournal article
thesis.degree.disciplineCommunity Health Sciences and Psychiatryeng
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