The Role of gastrointestinal peptides in regulating gallbladder transport function

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dc.contributor.advisorShaffer, Eldon
dc.contributor.authorKoziol, Kathie A. S.
dc.date.accessioned2005-07-21T19:37:45Z
dc.date.available2005-07-21T19:37:45Z
dc.date.issued1989
dc.descriptionBibliography: p. 82-90.en
dc.description.abstractThe transport of fluid and electrolytes across mammalian and amphibian gallbladder has been studied extensively as the gallbladder mucosa concentrates hepatic bile 8-10 fold yet bile remains isotonic to plasma. There is a net absorption of NaCl and NaHCO3 , whereas organic components like bile salts are retained against high concentration gradients. Active transport of Na+ and er is essential to the normal concentrating function of the gallbladder. The concentrated bile in this organ provides biological detergents for fat absorption in the duodenum and changes the physicochemical properties predisposing to nucleation of cholesterol from bile and hence gallstone formation. NaCl is believed to be absorbed by electroneutral coupled cotransport; Na+ is extruded across the basolateral membrane by the sodium pump (Na+-??-ATPase). An alternative double-exchange mechanism has been postulated (Na+ /H+ and c1· /HCO3 ·). Water movement is passive, following the osmotic gradients established by active electrolyte absorption. The normal regulation of Na+ and fluid absorption is poorly understood. Two candidate gut peptides were examined: secretin, which stimulates ductular bile flow in dogs, and VIP, which is thought to mediate secretion in cholecystitis. Both peptides act through cAMP. The Ussing chamber technique was used to assess transport in the gallbladder of the guinea pig. Using 22Na+ , sodium transport and short-circuit current (lsc) were measured and results plotted as a function of log doses of each peptide. The unstirred water layer, an important barrier to transport, was also quantitated.
dc.format.extentxi, 90 leaves : 30 cm.en
dc.identifier.citationKoziol, K. A. (1989). The Role of gastrointestinal peptides in regulating gallbladder transport function (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/19875en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/19875
dc.identifier.isbn0315503297en
dc.identifier.lccQP 185 K69 1989en
dc.identifier.urihttp://hdl.handle.net/1880/21628
dc.language.isoeng
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subject.lccQP 185 K69 1989en
dc.subject.lcshGallbladder
dc.subject.lcshGastrointestinal agents
dc.titleThe Role of gastrointestinal peptides in regulating gallbladder transport function
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
ucalgary.thesis.accessionTheses Collection 58.002:Box 703 520541625
ucalgary.thesis.notesoffsiteen
ucalgary.thesis.uarcreleaseyen
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