How Do Interactions Between Early Caregiving Environment and Genes Influence Health and Behavior?

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dc.contributor.authorLetourneau, Nicole
dc.contributor.authorGiesbrecht, Gerald
dc.contributor.authorBernier, Francois
dc.contributor.authorJoschko, Justin
dc.date.accessioned2016-01-04T20:44:37Z
dc.date.available2016-01-04T20:44:37Z
dc.date.issued2014
dc.descriptionArticle deposited according to publisher policies: https://us.sagepub.com/en-us/nam/the-green-route-%E2%80%93-open-access-archiving-policy. Article DOI 10.1177/1099800412463602en_US
dc.description.abstractTo promote optimal health and behavioral outcomes in children, nurses have long supported parents in providing the best possible care and nurturance to their offspring. A growing body of neuroscience research argues convincingly for the combined influences of genes and early caregiving on producing an individual’s unique health and behavioral phenotype. In this article, we systematically review studies that demonstrate the relationship between qualities of early caregiving and genetic propensity to health and behavioral outcomes. From an initial set of 255 articles, 24 articles met our inclusion criteria. The outcomes fall into four distinct groups: hypothalamic-pituitary-adrenal (HPA) response to stress, externalizing behavior, internalizing behavior, and disorganized attachment. In the articles, authors examined genes that code for the 5-hydroxy tryptamine (serotonin) transporter genes linked polymorphic region [5-HTTLPR] serotonin transporter promoter, D4 dopamine receptor, brain-derived neurotrophic factor, and monoamine oxidase A promoter. The reviewed studies suggest that the effect of the early rearing environment on gene expression relates mainly to HPA response to stress, whereas interactions between genes and caregiving mainly relate to behavior and attachment. Findings have implications for nurses focused on advocacy, prevention, and intervention to support the healthy development of children in families faced with adversity.en_US
dc.description.refereedYesen_US
dc.identifier.citationLetourneau, N., Giesbrecht, G.F., Joschko, J., Bernier, F. (2014). How do interactions between early caregiving environment and genes influence health and behavior? Biological Research for Nursing, 16(1; January), 83-94en_US
dc.identifier.doi10.1177/1099800412463602
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33635
dc.identifier.urihttp://hdl.handle.net/1880/51047
dc.language.isoenen_US
dc.publisherBiological Research for Nursingen_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.facultyNursingen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.urlhttp://brn.sagepub.com/en_US
dc.rightsAttribution Non-Commercial No Derivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEpigeneticsen_US
dc.subjectGene expressionen_US
dc.subjectGene-by-Environment interactionsen_US
dc.subjectEarly rearing environmentsen_US
dc.subjectAttachmenten_US
dc.titleHow Do Interactions Between Early Caregiving Environment and Genes Influence Health and Behavior?en_US
dc.typejournal article
thesis.degree.disciplinePaediatrics
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