Assessment of the Efficacy of MRI for Detectionof Changes in Bone Morphology in a MouseModel of Bone Injury

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dc.contributor.authorTaha, May A
dc.contributor.authorManske, Sarah
dc.contributor.authorKristensen, Erika
dc.contributor.authorTaiani, Jaymi
dc.contributor.authorKrawetz, Roman
dc.contributor.authorWu, Ying
dc.contributor.authorPonjevic, Dragana
dc.contributor.authorMatyas, John
dc.contributor.authorBoyd, Steven
dc.contributor.authorRancourt, Derrick
dc.contributor.authorDunn, Jeffrey F.
dc.date.accessioned2017-03-30T22:28:53Z
dc.date.available2017-03-30T22:28:53Z
dc.date.issued2013-07-11
dc.description"This is the peer reviewed version of the following article: [Taha, M. A., Manske, S. L., Kristensen, E., Taiani, J. T., Krawetz, R., Wu, Y., Ponjevic, D., Matyas, J. R., Boyd, S. K., Rancourt, D. E. and Dunn, J. F. (2013), Assessment of the efficacy of MRI for detection of changes in bone morphology in a mouse model of bone injury. J. Magn. Reson. Imaging, 38: 231–237], which has been published in final form at [http://dx.doi.org/10.1002/jmri.23876]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."en_US
dc.description.abstractPurpose To determine whether magnetic resonance imaging (MRI) could be used to track changes in skeletal morphology during bone healing using high-resolution micro-computed tomography (μCT) as a standard. We used a mouse model of bone injury to compare μCT with MRI. Materials and Methods Surgery was performed to induce a burr hole fracture in the mouse tibia. A selection of biomaterials was immediately implanted into the fractures. First we optimized the imaging sequences by testing different MRI pulse sequences. Then changes in bone morphology over the course of fracture repair were assessed using in vivo MRI and μCT. Histology was performed to validate the imaging outcomes. Results The rapid acquisition with relaxation enhancement (RARE) sequence provided sufficient contrast between bone and the surrounding tissues to clearly reveal the fracture. It allowed detection of the fracture clearly 1 and 14 days postsurgery and revealed soft tissue changes that were not clear on μCT. In MRI and μCT the fracture was seen at day 1 and partial healing was detected at day 14. Conclusion The RARE sequence was the most suitable for MRI bone imaging. It enabled the detection of hard and even soft tissue changes. These findings suggest that MRI could be an effective imaging modality for assessing changes in bone morphology and pathobiology.en_US
dc.description.grantingagencyCanadian Institutes of Health Research; Alberta Innovates Health Solutions Team in Osteoarthritisen_US
dc.description.refereedYesen_US
dc.identifier.citationTaha, M. A., Manske, S. L., Kristensen, E., Taiani, J. T., Krawetz, R., Wu, Y., Ponjevic, D., Matyas, J. R., Boyd, S. K., Rancourt, D. E. and Dunn, J. F. (2013), Assessment of the efficacy of MRI for detection of changes in bone morphology in a mouse model of bone injury. J. Magn. Reson. Imaging, 38: 231–237. doi:10.1002/jmri.23876en_US
dc.identifier.doi10.1002/jmri.23876
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33473
dc.identifier.issn1053-1807
dc.identifier.urihttp://hdl.handle.net/1880/51892
dc.language.isoenen_US
dc.publisherWileyen_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentRadiologyen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectMRIen_US
dc.subjectμCTen_US
dc.subjectstem cellsen_US
dc.subjectbone fractureen_US
dc.subjectspin-echoen_US
dc.subjectanimal modelen_US
dc.titleAssessment of the Efficacy of MRI for Detectionof Changes in Bone Morphology in a MouseModel of Bone Injuryen_US
dc.typejournal article
thesis.degree.disciplineRadiology / Physiology / Clinical Neurosciences
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