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Impact of Growth Hormone on Adult Bone Quality in Turner Syndrome - A High Resolution Peripheral Quantitative Computed Tomography Study

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ucalgary_2014_nour_munier.pdf (18.93Mb)
Advisor
Boyd, Steven K
Author
Nour, Munier Anwar
Accessioned
2014-02-03T19:28:55Z
Available
2014-03-15T07:00:21Z
Issued
2014-02-03
Submitted
2014
Other
Turner Syndrome
Osteoporosis
High Resolution Peripheral Quantitative Computed Tomography
Growth Hormone
Subject
Medicine and Surgery
Type
Thesis
Metadata
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Abstract
Caused by total or partial X-monosomy, Turner Syndrome (TS) is the most common chromosomal disorder in females. Commonly associated features include short stature, ovarian failure and osteoporosis in adult years. Childhood short-stature in TS is commonly treated with growth hormone (GH). This historic cohort-study using dual x-ray absorptiometry (DXA) and high resolution peripheral quantitative computed tomography (HR-pQCT) was conducted to determine the effect of childhood GH treatment on adult bone quality in TS women. Karyotype confirmed TS women aged 16-45 years were recruited (N=28). GH-treated subjects were 7.4 cm taller than non-GH-treated (p<0.05). Groups were similar in regard to known bone health risk factors. GH-treated subjects had significantly larger bone areas (9-25%, p<0.05) by DXA and HR-pQCT. Bone densities, micro-architecture and estimated fracture thresholds were not different among treatment groups. While no micro-architectural benefits were observed with GH-treatment, the persistent macro-structural differences may provide advantages in future fracture risk.
Corporate
University of Calgary
Faculty
Graduate Studies
Doi
http://dx.doi.org/10.11575/PRISM/26456
Uri
http://hdl.handle.net/11023/1363
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