Development and Microscaling of a Novel Glucose Biosensor for Application in a Minimally Invasive Sampling Platform

Date
2014-04-01
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Abstract
Diabetes Mellitus is approaching epidemic proportions in North America and many regions in the world. Current treatment involves self-monitoring of blood glucose levels by analysis of a blood sample obtained by "finger-pricking". This suffers from non-compliance, and samples at a rate much lower than the Shannon frequency of blood glucose levels. The e-Mosquito provides near-painless sampling, is apply-and-forget, and provides a higher sampling rate. This thesis concerns miniaturiziation of a novel glucose transducer, for integration in the e-Mosquito, that consists of iridium and glucose oxidase on a gold electrode, and which obeys Michaelis-Menten kinetics and were characterized using their Imax and Km values. The sensor includes this transducer, a micropotentiostat, a power supply, and an ADC that communicates with the e-Mosquito microprocessor. Testing of the transducer showed current densities of 250-400 uA/cm2, though with high inter-transducer variability. The potentiostat was also characterized and demonstrated to have adequate sensitivity and bandwidth.
Description
Keywords
Biochemistry, Engineering--Biomedical, Engineering--Electronics and Electrical
Citation
Jones, T. (2014). Development and Microscaling of a Novel Glucose Biosensor for Application in a Minimally Invasive Sampling Platform (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25644