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Exploring Protein O-GlcNAcylation as a Novel Diagnostic Tool for Type II Mellitus and the Impact of Exercise on Cardiac Protein O-GlcNAcylation

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Advisor
Shearer, Jane
Belke, Darrell
Author
Myslicki, Jason
Accessioned
2014-05-16T16:54:44Z
Available
2014-06-16T07:00:44Z
Issued
2014-05-16
Submitted
2014
Other
O-GlcNAc
Type II Diabetes Mellitus
Insulin Resistance
Exercise
post translational protein modification
Subject
Physiology
Type
Thesis
Metadata
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Abstract
The purpose of this study was to explore the sensitivity of O-linked β-N-acetylglucosamine (O-GlcNAc) in relation to various anthropometric and metabolic markers in healthy young adults and then to investigate how a chronic exercise regime affects this important post-translation signalling pathway in a Type II diabetic (T2DM) mouse model. Whole blood was collected from clinically healthy young adult males (n=24) and cardiac tissue was collected from diabetic (db/db) and control (db+) mice (n=9-10/group) that underwent six weeks of exercise or were designated sedentary. Western blot analysis was performed on all samples. Human whole blood exhibited greater sensitivity to Homeostatic Model of Assessment – Insulin Resistance (HOMA-IR) than Hemoglobin A1c (HbA1c) demonstrating its potential utility as a screening tool with strong diagnostic value. Six weeks of running wheel exercise did not alter protein O-GlcNAcylation in db/db or db+ mice. Protein O-GlcNAcylation is a valuable tool in assessing the efficacy of exercise in preventing T2DM.
Corporate
University of Calgary
Faculty
Graduate Studies
Doi
http://dx.doi.org/10.5072/PRISM/26098
Uri
http://hdl.handle.net/11023/1526
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