Elevated levels of lipids and lipoproteins have strong genetic determinants, and are key risk factors for cardiovascular disease. Study aims were to determine if young adults, when stratified by genotype at the rs646776 variant of the 1p13 locus, displayed differential postprandial responses to an oral fat tolerance test. Participants received a high fat mixed meal following an overnight fast and a fat-exclusion meal at 8 h postprandially. Blood samples were obtained at t=0, 2, 4, 6, 8 and 24 h for lipoprotein analyses via nuclear magnetic resonance profiling.
Carriers of the minor, protective allele (TC/CC) displayed lower concentrations of fasting and postprandial very-low density lipoproteins and chylomicrons, in addition to triglyceride content, compared to major, risk allele homozygotes (TT). We report a novel association between the SORT1 1p13 locus and postprandial lipaemia. These results provide evidence of decreased
exposure to atherogenic particles in carriers of the minor SORT1 allele, suggesting relative protection against cardiovascular disease compared to TT homozygotes.