The Influence of Childhood Conjugate Vaccine Introduction on Invasive Pneumococcal Disease (IPD) in Adults with Underlying Comorbidities

Date
2014-09-29
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Abstract
After introduction of pneumococcal conjugate vaccine (PCV) into routine childhood immunization programs, there has been a substantial decline in vaccine-serotype invasive pneumococcal disease (IPD) in vaccinated children and in unvaccinated persons. However, indirect protection may be relatively reduced in adults with underlying comorbidities. Data from a prospective, population-based surveillance system were analyzed using an indirect cohort study design. There were 1153 adult IPD cases from January 2000 to December 2011. The proportion of cases with immunocompetent comorbidities in the post-PCV era did not differ from that in the pre-PCV period (OR 1.10; 95% CI: 0.72-1.67). There was a non-significant increase in the proportion of cases with immunocompromising comorbidities (RRR 1.69; 95% CI: 0.79-3.60). This observed increase, from 25.5% in the pre-PCV period to 31.1% in the post PCV-13 period, was largely due to non-PCV serotype disease. Childhood PCV programs have provided considerable benefit, but the relative burden of IPD in immunocompromised adults may be increasing.
Description
Keywords
Epidemiology, Public Health
Citation
Cabaj, J. (2014). The Influence of Childhood Conjugate Vaccine Introduction on Invasive Pneumococcal Disease (IPD) in Adults with Underlying Comorbidities (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28204