Resting-State Functional Magnetic Resonance Imaging of Motor Networks in Perinatal Stroke
Date
2014-09-30
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Perinatal stroke is a focal brain injury that causes lifelong disability, including hemiparetic cerebral palsy. Arterial and venous strokes can both damage motor pathways. However, they differ in location and timing, potentially leading to distinct mechanisms of developmental plasticity that determine motor outcome. Existing models of post-stroke neuroplasticity lack an understanding of the functional networks that ultimately determine motor function. This study used resting-state functional magnetic resonance imaging to examine motor network functional connectivity patterns in perinatal stroke patients and to determine if there is a relationship between the functional connection strength and motor outcome. Significant differences in motor network connections were observed between stroke patients and healthy control subjects. No significant relationship was observed between functional connection strength and motor outcome scores. The results of this study serve as a foundation to better understand how resting-state functional imaging can assess motor function and the effects of interventional post-stroke therapies.
Description
Keywords
Human Development, Medicine and Surgery, Rehabilitation and Therapy
Citation
Saunders, J. K. (2014). Resting-State Functional Magnetic Resonance Imaging of Motor Networks in Perinatal Stroke (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27655