Temporal Mapping of Acute Stress-Induced Central and Circulating Cytokine Production
Date
2014-09-30
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Abstract
There is now a growing body of literature that indicates that stress can initiate inflammatory processes, both in the periphery and brain; however, the spatiotemporal nature of this response is not well characterized. Therefore, the aim of this study is to examine the effects of an acute psychological stress on changes in mRNA and protein levels of inflammatory mediators across a wide temporal range, in key corticolimbic brain regions regulating stress (amygdala, hippocampus, hypothalamus, prefrontal cortex). mRNA levels of inflammatory mediators were analyzed immediately following 30 minutes or 2 hours of acute restraint stress and protein levels were examined 0 hours through 24 hours post termination of 2 hours of acute restraint stress using multiplex and ELISA methods. While the results are not completely consistent across all methods utilized, the results show a general increase in inflammatory mediators in circulation and in the amygdala and decrease in the prefrontal cortex.
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Psychobiology
Citation
Vecchiarelli, H. (2014). Temporal Mapping of Acute Stress-Induced Central and Circulating Cytokine Production (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27994