Ketamine for Acute-on-Chronic Pain
Date
2015-04-20
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Ketamine is a N-methyl D-aspartate antagonist that blocks pain stimuli transmission and could prove useful for the complex treatment of acute-on-chronic pain.
Setting: A low-dose ketamine protocol as an adjunct to conventional treatment was implemented in a major urban center.
Aim: To explore the research question “what is the effect of low-dose ketamine continuous intravenous infusions on pain of highly opioid tolerant adults following spinal surgery?”
Participants: All patients had spine surgery and used a minimum of 100mg of oral morphine equivalent pre-operatively.
Methods: A retrospective chart review was conducted. Data from individuals treated with conventional therapy from the year prior to protocol implementation were compared to data from those who also received ketamine post-implementation. Outcome measures included pain scores and daily opioid consumption on post-operative day 0 through 5, time to ambulation, time to discharge and adverse effects.
Results: There were no statistically significant differences between conventional therapy and ketamine patients.
Description
Keywords
Nursing
Citation
Vaid, P. (2015). Ketamine for Acute-on-Chronic Pain (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26699