Plasma Metabolomics of Community Acquired Pneumonia (CAP) For Prognosis of Patients at Highest Risk of Mortality

Date
2015-07-13
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Abstract
Community acquired pneumonia (CAP) is an acute disease with clinical features of lower respiratory tract infections. Early and accurate prognoses, and effective treatment, where possible, in the management of CAP are essential to decrease mortality. Metabolomic analysis is defined as the comprehensive study of low molecular-weight metabolites present in biological samples that enable the qualitative and/or quantitative measurement and analysis of multiple metabolites We showed the feasibility of metabolomics using nuclear magnetic resonance (NMR) spectroscopy, gas chromatography mass spectrometry (GC-MS) and direct infusion tandem mass spectrometry (DIMS/MS) as most common analytical platforms in association with multivariate statistical analysis to separate non-survivors and survivor of bacteria CAP and H1N1 pneumonia patients for prognosis of mortality. In conclusion, this study may not only be instrumental in predicting the mortality of CAP patients within 24 hours of hospitalization, but may also allow for the rapid identification of the infective organism in CAP.
Description
Keywords
Biology--Molecular, Health Care Management, Biochemistry
Citation
Banoei, M. M. (2015). Plasma Metabolomics of Community Acquired Pneumonia (CAP) For Prognosis of Patients at Highest Risk of Mortality (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27367