Neuroimaging Biomarkers of Alzheimer’s Disease and Cerebrovascular Disease in Patients with Subjective Cognitive Concerns and Mild Cognitive Impairment
Date
2015-09-02
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Abstract
In these studies, patients with subjective cognitive concerns (SCC; n = 43) and mild cognitive impairment (MCI; n = 18), were compared using neuroimaging biomarkers for β-amyloid, white matter hyperintensities (WMH) of presumed vascular origin, and cerebral perfusion. Higher WMH burden was found in SCC compared to MCI (p = 0.02). In the whole cohort, there was a correlation between higher β-amyloid accumulation and lower left (p = 0.02) and right temporal gyrus perfusion (p = 0.05), while higher WMH burden was associated with lower perfusion in the cortical grey matter (p = 0.01), posterior cingulate cortex (p = 0.02) and right temporal gyrus (p = 0.01). Exploratory comparisons suggested lower perfusion in the left temporal gyrus and anterior cingulate cortex in amnestic MCI (n = 12) compared to non-amnestic MCI (n = 6). These findings suggest that pathologies consistent with dementia are evident in early cognitive decline.
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Medicine and Surgery
Citation
Wang, X. R. (2015). Neuroimaging Biomarkers of Alzheimer’s Disease and Cerebrovascular Disease in Patients with Subjective Cognitive Concerns and Mild Cognitive Impairment (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27084