A Single Fiber System for Monitoring Tissue Oxygen Saturation
Date
2015-09-28
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Abstract
Oxygen saturation is an important biological marker in tissue and is often quantified using optical imaging of intrinsic signals. However, due to the scattering property of biological tissue, most optical functional imaging methods are limited to the surface of the brain or have poor resolution.
In this work, a single fiber optical system with zero source-detector separation is presented. The system is designed for measuring the oxygen saturation of deep brain structures by implanting the small diameter fiber probe into the tissue of interest. The system measures oxygen saturation using a steady-state spectroscopy method based on the absorption properties of oxy-hemoglobin and deoxy-hemoglobin.
This thesis covers: (a) system design, including the optical simulation, system components and performance; (b) Monte Carlo simulations for wavelength determination, depth penetration and the received signal; (c) quantification method for the single fiber system; and (d) experimental results in a tissue phantom.
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Keywords
Engineering--Biomedical, Engineering--Electronics and Electrical
Citation
Yu, L. (2015). A Single Fiber System for Monitoring Tissue Oxygen Saturation (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25007