Using 9.4T MRI To Investigate Parenchymal And Vascular Changes In An Animal Model Of Pediatric Mild Traumatic Brain Injury

Date
2015-12-22
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Mild traumatic brain injury (mTBI) is the most common form of brain injury in Canada. No standard CT or MRI methods can identify or monitor mTBI. It is necessary to develop methods to identify patients at risk of long term problems and monitor treatment. Evidence exists for abnormal blood flow post-mTBI, therefore we hypothesized that 24 hr after injury there would be abnormal vascular regulation with no parenchymal changes. Juvenile rats bred in house and ordered from a supplier sustained a mTBI or a sham injury using a weight drop model. Animals were imaged 24hr later using a 9.4T MRI. No structural changes were evident using standard MRI sequences, supporting the model as being consistent with clinical case of mTBI. mTBI bred rats had a larger sagittal sinus size. The larger sinus size in mTBI compared to control rats potentially suggests cerebrovenous dysregulation which could relate to mTBI symptomology.
Description
Keywords
Neuroscience
Citation
Imhof, E. (2015). Using 9.4T MRI To Investigate Parenchymal And Vascular Changes In An Animal Model Of Pediatric Mild Traumatic Brain Injury (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28614