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dc.contributor.advisorHabibi, Hamid
dc.contributor.authorAlhawsawi, Abeer
dc.date.accessioned2016-05-17T14:41:05Z
dc.date.available2016-05-17T14:41:05Z
dc.date.issued2016
dc.date.submitted2016en
dc.identifier.citationAlhawsawi, A. (2016). The Role of GnIH in Paracrine/Autocrine Control of Ovarian Function in Zebrafish (Danio rerio) (Unpublished master's thesis). University of Calgary, Calgary, AB. doi:10.11575/PRISM/28325en_US
dc.identifier.urihttp://hdl.handle.net/11023/3015
dc.description.abstractGonadotropin inhibitory hormone (GnIH) is a hypothalamic neuropeptide, termed for its observed inhibitory effect on the luteinizing hormone release from cultured pituitary of Japanese quail when it was first discovered in 2000. In vertebrates including fish, GnIH has been found in extra-hypothalamic tissues including gonads, however, information regarding the role of this peptide as extra-pituitary regulator of gonadal function is not available and require further research. The goal of my thesis was to investigate direct action of GnIH, in vitro, on ovarian steroidogenesis, final oocyte maturation, and gene expression using sexually mature zebrafish. In the present study, GnIH did not significantly affect transcript levels for genes involved in the control of gonadal function and steroid biosynthesis. However, GnIH significantly altered hCG-induced estradiol (E2) release and resumption of meiosis. Thus, the findings provide a support for the hypothesis that GnIH plays paracrine/autocrine role in the regulation of ovarian function in zebrafish.en_US
dc.language.isoeng
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEducation--Sciences
dc.subjectPhysiology
dc.subjectZoology
dc.titleThe Role of GnIH in Paracrine/Autocrine Control of Ovarian Function in Zebrafish (Danio rerio)
dc.typemaster thesis
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28325
thesis.degree.nameMaster of Science
thesis.degree.nameMS
thesis.degree.nameMSc
thesis.degree.disciplineBiological Sciences
thesis.degree.grantorUniversity of Calgary
atmire.migration.oldid4432
dc.publisher.placeCalgaryen
ucalgary.item.requestcopytrue


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