There have been intense research efforts on developing compact and low-cost supercontinuum generation (SCG) systems, which have various application areas including telecommunications, spectroscopy, and optical coherence tomography. This research employs complementary metal–oxide–semiconductor (CMOS) technology to design and implement two integrated laser diode drivers for reducing the size and cost of SCG systems. A continuous-wave CMOS driver with a maximum output current of 600 mA is developed for driving a laser diode in an erbium-doped fiber amplifier (EDFA). A picosecond pulsed CMOS driver is designed and applied for gain-switching a laser diode to produce optical pulses with a pulse width of 200 ps and a repetition rate of 5.6 MHz. The gain-switched laser diode output is amplified by an EDFA and then launched into a highly nonlinear fiber for SCG. The generated supercontinuum has an average power of 62 mW and a spectral bandwidth of 806 nm.