Rhinovirus-Bacteria Co-Exposure Modulates CCL20 Induction From Human Bronchial Epithelial Cells

Date
2016
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Volume Title
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Abstract
Exacerbations of chronic obstructive pulmonary disease (COPD) are often triggered by infection by viral or bacterial pathogens, with human rhinovirus (HRV) and nontypeable Haemophilus influenzae (NTHI) among the most commonly detected pathogens. Patients who suffer from concurrent viral and bacterial infection have more severe exacerbations. CCL20 is a chemokine that attracts immature dendritic cells to the airways, acts as an antimicrobial, and so contributes to both innate and adaptive immune responses to infection. In this thesis, we determined what effect co-infection of human bronchial epithelial (HBE) cells with HRV and bacteria would have on CCL20 induction. HRV/bacterial co-infection resulted in synergistic CCL20 induction in response more than one HRV or bacterial strain. Synergistic CCL20 induction was transcriptionally regulated, and induction was inhibited by cigarette smoke extract (CSE). Impaired induction of CCL20 by CSE raises the prospect of weakened antimicrobial immunity during infections in smokers and patients with COPD.
Description
Keywords
Microbiology, Immunology
Citation
Maciejewski, B. (2016). Rhinovirus-Bacteria Co-Exposure Modulates CCL20 Induction From Human Bronchial Epithelial Cells (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27664