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Morphology and Dental Function in a BMP7 Rodent Knockout Model and Implications for Mammalian Tooth Evolution

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ucalgary_2016_zurowski_chelsey.pdf (17.09Mb)
Advisor
Theodor, Jessica
Jamniczky, Heather
Author
Zurowski, Chelsey
Committee Member
Rogers, Sean
Graf, Daniel
Other
Bone Morphogenetic Protein 7
Tooth Evolution
Mammal Evolution
Tooth Development
BMP7
Tooth Wear
Dental Adaptation
Subject
Biology
Anatomy
Ecology
Zoology
Paleontology
Type
Thesis
Metadata
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Abstract
Tooth morphology is the result of tissue interactions, many of which involve families of regulatory genes that pattern development. Determining and quantifying the effect of regulatory genes has implications for understanding the mechanisms driving the degree of diversity observed in mammalian dentition. Bone morphogenetic protein 7 (BMP7) is one regulatory gene that is active in the developing tooth. I characterized the morphology and assessed the function of the dentition in BMP7 conditional knockout mice. Mutant molars had short, broad cusps, and extra cusps on the M1 and m1. Wear facets in the mutant mice were different in shape and in the direction that they faced on the tooth. This shows that changes in the expression of BMP7 lead to changes in the morphology and function of the dentition, suggesting that BMP7 could have acted in structuring the amount of dental diversity that is apparent in extinct and extant mammals.
Corporate
University of Calgary
Faculty
Graduate Studies
Doi
http://dx.doi.org/10.5072/PRISM/27008
Uri
http://hdl.handle.net/11023/3264
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