Hip Derived Synovial Mesenchymal Progenitor Cell Surface Markers In Situ as Indicators for Differentiation Potential
Abstract
The degeneration of articular cartilage observed in patients with osteoarthritic (OA) joints coupled with the lack of regenerative abilities of cartilage play a major role in causing disability in OA patients. The synovial membrane within the joints is home to synovial mesenchymal progenitor cell (sMPC) populations that have the ability to undergo chondrogenesis (in vivo and in vitro). However, it remains unknown if these sMPCs express any markers in vivo/in situ that give information as to which of the specific MPC sub-populations have pro-chondrogenic capacity. In the patient cohort examined in this study, the most common cell surface marker profile on MPCs was determined to be CD90+/CD44+/CD73+, and though it included cells that had chondrogenic capacity, it also included cells that did not. Additional markers are therefore required to further discriminate the heterogeneous populations of MPCs and identify synovial MPCs that are enriched for chondrogenic capacity.
Description
Keywords
Engineering--Biomedical
Citation
Affan, A. (2016). Hip Derived Synovial Mesenchymal Progenitor Cell Surface Markers In Situ as Indicators for Differentiation Potential (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26371