Acute Impaired Glucoregulation and Disrupted Gastrointestinal Hormone Secretion in Adolescents in Response to Caffeine-Containing and Nutritionally Fortified “Energy Shots”
Abstract
Caffeine-containing energy drinks (CCED) are beverages containing simple sugars, caffeine and mixtures of vitamin, mineral and/or herbal preparations which are aggressively marketed to adolescents and young adults. This study analyzed the metabolic impact of acute, non-nutritive sweetener-containing CCED consumption on glucoregulation and gut peptide response in adolescents, and how it is affected by genetic variance. CCED consumption induced acute insulin resistance following an oral glucose tolerance test when compared with placebo, with glucose and insulin concentrations rising by 15.8% and 73.0%, respectively. Glucagon-like peptide-1, gastric inhibitory peptide, C-peptide, and pancreatic peptide YY concentrations rose following caffeine and decaffeinated treatments when compared with placebo. Genetically fast caffeine metabolizers had exaggerated glucose and insulin curves following caffeine trials, while slow metabolizers were relatively unchanged. This response to CCED consumption could be detrimental to individuals predisposed to metabolic deficits. Results provoke further exploration into the mechanisms involved in this transient insulin resistance.
Description
Keywords
Genetics, Physiology, Nutrition, Public Health
Citation
Virtanen, H. (2017). Acute Impaired Glucoregulation and Disrupted Gastrointestinal Hormone Secretion in Adolescents in Response to Caffeine-Containing and Nutritionally Fortified “Energy Shots” (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/24696