New ileostomy formation and subsequent community-onset acute and chronic kidney disease: A population-based cohort study
Abstract
Ileostomy formation results in a loss of colonic absorptive capacity, which may
cause volume depletion and kidney disease; however, associations with acute
kidney injury (AKI) and chronic kidney disease (CKD) are uncertain. This thesis
reports a population-based cohort study that characterizes the relationships
between ileostomy formation and subsequent community-onset AKI and CKD. A
total of 19,889 patients that underwent surgery in Alberta, Canada between May
2002 and January 2015 were included; 4136 patients that underwent ileostomy
formation were compared to 15,753 patients that underwent bowel resection
without ileostomy formation. After statistical adjustment using logistic regression,
ileostomy formation was associated with subsequent community-onset AKI
(OR=4.08; 95% CI=3.62-4.61) and CKD (OR=4.71; 95% CI=3.84-5.77). A series of
risk prediction models of these outcomes after ileostomy formation were
subsequently developed and evaluated. Clinicians should be vigilant for kidney
disease following ileostomy formation and future studies should focus on
developing preventative strategies.
Description
Keywords
Medicine and Surgery
Citation
Smith, S. (2017). New ileostomy formation and subsequent community-onset acute and chronic kidney disease: A population-based cohort study (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27092