Conductance and Capacitance Effects of Acute, Electrical, Carotid Baroreflex Stimulation
Date
2013-04-16
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Abstract
Baroreflex activation therapy (BAT) is effective in resistant hypertension; we hypothesized that BAT increases both venous capacitance and arterial conductance. We measured aortic pressure and flow and inferior vena caval flow and used a modified Brooksby-Donald technique to evaluate sub-diaphragmatic blood volume. Data were recorded with BAT, and with sodium nitroprusside (SNP) and Angiotensin II (Ang II) infusions, alone and with BAT.
BAT substantially increased venous capacitance and arterial conductance. SNP also increased venous capacitance and arterial conductance. During SNP infusion BAT remained effective, further decreasing blood pressure and increasing capacitance and conductance. Ang II decreased both capacitance and conductance. During Ang II infusion, increased BAT reversed the decrease in venous capacitance while restoring BP completely and conductance to 80% of baseline.
BAT decreases blood pressure and increases arterial conductance and venous capacitance, even when combined with powerful vasoactive drugs. These may be important effects in hypertension.
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Animal Physiology, Medicine and Surgery, Engineering--Biomedical
Citation
Burgoyne, S. J. (2013). Conductance and Capacitance Effects of Acute, Electrical, Carotid Baroreflex Stimulation (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25413