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The role of oral contraceptives in optic neuritis: the story behind the study, initial experiences, and lessons learned

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Advisor
Costello, Fiona
Burton, Jodie
Author
Trufyn, Jessie J.
Accessioned
2013-07-15T20:31:00Z
Available
2013-11-12T08:00:16Z
Issued
2013-07-15
Submitted
2013
Other
multiple sclerosis
optic neuritis
sex hormones
oral contraceptives
lessons learned
Subject
Neuroscience
Type
Thesis
Metadata
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Abstract
There is accumulating evidence of sex differences in multiple sclerosis, making hormones a possible research avenue for therapeutic agents. Oral contraceptives are a source of synthetic hormones, however, it is unclear whether hormone-based therapies help, hinder, or have no effect on the disease in women. In an attempt to elucidate the role of sex hormones, we are currently conducting an observational study of oral contraceptives in optic neuritis, a condition that often occurs in parallel with multiple sclerosis. The thesis describes the study rational and supporting evidence for the hypothesis that oral contraceptive use in our study population will be associated with beneficial outcomes. I also share experiences with study implementation and preliminary data. The final section of the thesis offers insight for researchers on the areas of optical coherence tomography, hormones, and human research.
Corporate
University of Calgary
Faculty
Graduate Studies
Doi
http://dx.doi.org/10.11575/PRISM/28340
Uri
http://hdl.handle.net/11023/817
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