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dc.contributor.advisorRho, Jong
dc.contributor.authorSmith, Jacklyn Dianna
dc.date.accessioned2013-07-15T22:35:56Z
dc.date.available2013-11-12T08:00:16Z
dc.date.issued2013-07-15
dc.date.submitted2013en
dc.identifier.citationSmith, J. D. (2013). Dietary treatment and pharmacological intervention for core behaviours in the BTBR T+Itpr3tf/J mouse model of autism (Unpublished master's thesis). University of Calgary, Calgary, AB. doi:10.11575/PRISM/25705en_US
dc.identifier.urihttp://hdl.handle.net/11023/830
dc.description.abstractAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by abnormal social interaction, communication and repetitive behaviours (Currenti, 2010). There are no definitive causes of ASD, although alterations in genetics, cortical excitability, neuronal structure and development have been described (Courchesne et al., 2007). Mouse models are a powerful tool in analyzing gene products, behaviours and neuroanatomical associations relevant to ASD. The BTBR T+Itpr3tf/J mouse model of autism displays all three hallmark features (Ellegood, Babineau, Henkelman, Lerch, & Crawley, 2013; McFarlane et al., 2008). The ketogenic diet has now been implicated in improving behavioural outcomes in developmental disorders (Evangeliou et al., 2003). Moreover, there are a limited number of studies indicating its effects on animal models (Masino & Rho, 2012). The work presented here investigates ketogenic diet and pharmacological treatment effects on social and repetitive behaviour, cortical excitability and motor map representation in the BTBR T+Itpr3tf/J mouse model of ASD.en_US
dc.language.isoeng
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subjectPsychology--Behavioral
dc.subject.classificationAutismen_US
dc.subject.classificationKetogenic Dieten_US
dc.subject.classificationAnimal Modelsen_US
dc.titleDietary treatment and pharmacological intervention for core behaviours in the BTBR T+Itpr3tf/J mouse model of autism
dc.typemaster thesis
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25705
thesis.degree.nameMaster of Science
thesis.degree.nameMS
thesis.degree.nameMSc
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
atmire.migration.oldid1154
dc.publisher.placeCalgaryen


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