Effects of a Maternal Pre-pregnancy Dietary and Pharmacological Intervention on Maternal Fecundity and Offspring Health in Sprague-Dawley Rats

Date
2013-09-13
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Abstract
The objective of this study was to determine if a combined oligofructose and sitagliptin pre-pregnancy intervention could mitigate the decreased fecundity, poor pregnancy outcomes and negative offspring health outcomes associated with maternal obesity. Obese female Sprague-Dawley rats were randomized to 1 of 6 groups: 1) AIN-93 (Control-Treated Obese); 2) OFS (Fibre-Treated Obese); 3) Sitagliptin (Drug-Treated Obese); 4) OFS+Sitagliptin (Combination-Treated Obese); 5) Caloric restriction (Weight-Matched to group 4), 6) High fat & sucrose (Obese Untreated). A lean reference group was also included. Pups consumed a HFS diet for 6 weeks in adulthood. Reduced blood glucose was seen in sitagliptin offspring and increased short-chain fatty acid receptor expression and Bifidobacteria seen in offspring of the combination treated dams. Despite these changes, the pre-pregnancy treatments investigated in this study did not lead to meaningful improvements in maternal fecundity, pregnancy outcomes or offspring health.
Description
Keywords
Animal Physiology, Human Development, Nutrition
Citation
Dennison, C. (2013). Effects of a Maternal Pre-pregnancy Dietary and Pharmacological Intervention on Maternal Fecundity and Offspring Health in Sprague-Dawley Rats (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25816