Cumming School of Medicine Research & Publications

 

Recent Submissions

  • Acellular pertussis vaccine effectiveness and waning immunity in Alberta, Canada: 2010–2015, a Canadian Immunization Research Network (CIRN) study 

    Bell, Christopher A.; Russell, Margaret L.; Drews, Steven J.; Simmonds, Kimberley A.; Svenson, Lawrence W.; Schwartz, Kevin L.; Kwong, Jeffrey C.; Mahmud, Salaheddin M.; Crowcroft, Natasha S. (University of Calgary, University of Alberta Hospital, Alberta Health Services, Alberta Ministry of Health, University of Toronto, Public Health Ontario, University of Manitoba, Post-print, 2019-06-01)
    Background Pertussis is still frequently reported in Canada. In Alberta, pertussis incidence ranged from 1.8 to 20.5 cases per 100,000 persons for 2004–2015. Most cases occurred in those aged <15 years. In Alberta, acellular ...

  • Antigenic variation in the Lyme spirochete: detailed functional assessment of recombinational switching at vlsE in the JD1 strain of Borrelia burgdorferi 

    Verhey, Theodore B; Castellanos, Mildred; Chaconas, George (Wiley, Cumming School of Medicine, Biochemistry & Molecular Biology, Microbiology, Immunology & Infectious Diseases, University of Calgary, https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html, Post-print, 2019-01)
    Borrelia burgdorferi is a causative agent of Lyme disease and establishes long-term infection in mammalian hosts. Persistence is promoted by the VlsE antigenic variation system, which generates combinatorial diversity of ...

  • METRICS: a pattern language of scholarship in medical education 

    Ellaway, Rachel H.; Topps, David A. (Cumming School of Medicine, Other, University of Calgary, Publisher's version, 2017-11-07)
    Scholarly activity in health professions education has been growing steadily but despite the broad interest, quite what is considered to be scholarly activity in medical education has remained vague. Boyer’s classes of ...

  • Abstract booklet from the 2019 Sebastian K. Littmann Research Day 

    Patten, Scott B. (Cumming School of Medicine, University of Calgary, 2019-03-01)

  • Application of immobilized ATP to the study of NLRP inflammasomes 

    Liao, Kuo Chieh; Sandall, Christina F.; Carlson, David A.; Ulke-Lemée, Annegret; Platnich, Jaye; Hughes, Philip Floyd; Muruve, Daniel A.; Haystead, Timothy Arthur James; MacDonald, Justin Anthony (Cumming School of Medicine, Biochemistry & Molecular Biology, University of Calgary, Duke University, 2019-01-11)
    The NLRP proteins are a subfamily of the NOD-like receptor (NLR) innate immune sensors that possess an ATP-binding NACHT domain. As the most well-studied member, NLRP3 can initiate the assembly process of a multiprotein ...

  • Effects of phosphorylation on the NLRP3 inflammasome 

    Sandall, Christina F.; MacDonald, Justin Anthony (Cumming School of Medicine, Biochemistry & Molecular Biology, University of Calgary, 2019-03-05)
    The pyrin domain containing Nod-like receptors (NLRPs) are a family of pattern recognition receptors known to regulate an array of immune signaling pathways. Emergent studies demonstrate the potential for regulatory control ...

  • Targeting Pim kinases and DAPK3 to control hypertension 

    Carlson, David A.; Singer, Miriam R.; Sutherland, Cindy; Redondo, Clara; Alexander, Leila T.; Hughes, Philip Floyd; Knapp, Stefan; Gurley, Susan B.; Sparks, Matthew A.; MacDonald, Justin Anthony; Haystead, Timothy Arthur James (Cumming School of Medicine, Biochemistry & Molecular Biology, University of Calgary, Duke University Medical Center, University of Oxford, 2018-07-04)
    Sustained vascular smooth muscle hypercontractility promotes hypertension and cardiovascular disease. The etiology of hypercontractility is not completely understood. New therapeutic targets remain vitally important for ...

  • Young children in different linguistic environments: A multimodal neuroimaging study of the inferior frontal gyrus 

    Thieba, Camilia; Long, Xiangyu; Dewey, Deborah; Lebel, Catherine A. (Cumming School of Medicine, Community Health Sciences, Paediatrics, Radiology, University of Calgary, 2018-07-11)
    Magnetic resonance imaging (MRI) studies show that bilingual adults display structural and functional brain alterations, especially in the inferior frontal gyrus (IFG), dependent on when they learned their second language. ...

  • Brain white matter structure and language ability in preschool-aged children 

    Walton, Matthew; Dewey, Deborah; Lebel, Catherine A. (Cumming School of Medicine, Radiology, University of Calgary, Post-print, 2018-01)
    Brain alterations are associated with reading and language difficulties in older children, but little research has investigated relationships between early language skills and brain white matter structure during the preschool ...

  • The Prevalence and Incidence of Dementia: a Systematic Review and Meta-analysis 

    Fiest, Kirsten M.; Jette, Nathalie; Roberts, Jodie I.; Maxwell, Colleen J.; Smith, Eric E.; Black, Sandra E.; Blaikie, Laura; Cohen, Adrienne; Day, Lundy; Holroyd-Leduc, Jayna; Kirk, Andrew; Pearson, Dawn; Pringsheim, Tamara; Venegas-Torres, Andres; Hogan, David B. (CAMBRIDGE UNIV PRESS, Cumming School of Medicine, Critical Care Medicine, https://www.cambridge.org/core/services/open-access-policies, Published version, 2016)
    Introduction: Dementia is a common neurological condition affecting many older individuals that leads to a loss of independence, diminished quality of life, premature mortality, caregiver burden and high levels of healthcare ...

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