Recent Submissions

  • Scanning mutagenesis of the I-II loop of the Cav2.2 calcium channel identifies residues Arginine 376 and Valine 416 as molecular determinants of voltage dependent G protein inhibition 

    Tedford, Hugo William; Kisilevsky, Alexandra E.; Vieira, Luciene Bruno; Varela, Diego L.; Chen, Lina; Zamponi, Gerald W. (BioMed Central Ltd., Cumming School of Medicine, Physiology & Pharmacology, University of Calgary, 2010-02-03)
    Direct interaction with the beta subunit of the heterotrimeric G protein complex causes voltage-dependent inhibition of N-type calcium channels. To further characterize the molecular determinants of this interaction, we ...
  • Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits 

    Piña-Crespo, Juan C.; Talantova, Maria V.; Micu, Ileana; States, Bradley A.; Chen, Huei Sheng Vincent; Tu, Shichun; Nakanishi, Nobuki; Tong, Gary G.; Zhang, Dongxian; Heinemann, Stephen F.; Zamponi, Gerald W.; Stys, Peter K.; Lipton, Stuart A. (Society for Neuroscience, Cumming School of Medicine, Physiology & Pharmacology, University of Calgary, 2010-08-25)
    NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits. ...
  • Regulation of calcium channels by RGK proteins 

    Flynn, Robyn E.; Zamponi, Gerald W. (Taylor and Francis, Cumming School of Medicine, Physiology & Pharmacology, University of Calgary, 2010-12-01)
    The RGK family of proteins, small GTPases of the Ras superfamily, are known to regulate calcium currents. It is commonly thought that this is due to an interaction with the Cavβ subunit, however, the mechanism of this ...
  • Antiallodynic effects of a confused α-conotoxin: Vc1.1 relieves neuropathic pain via off target actions on GABA(B) receptors and N-type channels 

    Zamponi, Gerald W. (Elsevier, Cumming School of Medicine, Physiology & Pharmacology, University of Calgary, 2011-02-01)
  • The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels 

    Altier, Christophe; You, Haitao; Chen, Lina; Walcher, Jan; Hermosilla, Tamara; García-Caballero, Agustín; Simms, Brent A.; Tedford, H. William; Zamponi, Gerald W. (Nature, Cumming School of Medicine, Physiology & Pharmacology, University of Calgary, 2011-02)
    It is well established that the auxiliary Cavβ subunit regulates calcium channel density in the plasma membrane, but the cellular mechanism by which this occurs has remained unclear. We found that the Cavβ subunit increased ...
  • L-type calcium channel β subunit modulates angiotensin II responses in cardiomyocytes 

    Hermosilla, Tamara; Moreno, Cristian; Itfinca, Mircea; Altier, Christophe; Armisén, Ricardo; Stutzin, Andrés; Zamponi, Gerald W.; Varela, Diego L. (Taylor and Francis, Cumming School of Medicine, Physiology & Pharmacology, University of Calgary, 2011-05)
    Angiotensin II regulation of L-type calcium currents in cardiac muscle is controversial and the underlying signaling events are not completely understood. Moreover, the possible role of auxiliary subunit composition of the ...
  • Signaling complexes of voltage-gated calcium channels 

    Turner, Ray W.; Anderson, Dustin M.; Zamponi, Gerald W. (Taylor and Francis, Cumming School of Medicine, Cell Biology & Anatomy, University of Calgary, 2011-09)
    Voltage gated calcium channels are key mediators of depolarization induced calcium entry into electrically excitable cells. There is increasing evidence that voltage gated calcium channels, like many other types of ionic ...
  • Trafficking and stability of voltage-gated calcium channels 

    Simms, Brent A.; Zamponi, Gerald W. (Elsevier, Cumming School of Medicine, University of Calgary, 2012-03-01)
    Voltage-gated calcium channels are important mediators of calcium influx into electrically excitable cells. The amount of calcium entering through this family of channel proteins is not only determined by the functional ...
  • Perceiving Pain: Health, Culture and Ritual 

    Houser, Dan E.; Zamponi, Gerald W. (Antrocom Onlus, Cumming School of Medicine, Physiology & Pharmacology, University of Calgary, 2011-01-01)
    For most of us, coming into contact with some form of pain is a daily occurrence: it is both a usual part of the human experience and lexicon. Not surprisingly, pain has many differing and contextually specific meanings, ...
  • Depressive-like behaviour of mice lacking cellular prion protein 

    Bonfield, Stephan P.; Zamponi, Gerald W.; Gadotti, Vinícius Maria (Elsevier, Cumming School of Medicine, Physiology & Pharmacology, University of Calgary, 2012-02)
    Cellular Prion Protein (PrP(C)) is known to mediate a protective role in several neurological conditions such as ischemia and epilepsy. However, so far, little information is available concerning the role of PrP(C) in ...

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