Science Research & Publications
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Visualizations as Data Input?
(Science, Computer Science, University of Calgary, Telecom Paris - Institut Polytechnique de Paris CNRS I3, 2021-10-01)We examine “input visualizations”, visual representations that are designed to collect (and represent) new data rather than encode pre-existing datasets. Information visualization is commonly used to reveal insights and ... -
Alkalinity Generation Constraints on Basalt Carbonation for Carbon Dioxide Removal at the Gigaton-per-Year Scale
(Science, Geoscience, University of Calgary, 2021-08-20)The world adds about 51 Gt of greenhouse gases to the atmosphere each year, which will yield dire global consequences without aggressive action in the form of carbon dioxide removal (CDR) and other technologies. A suggested ... -
Mineralogical characterization and thermodynamic modelling of scales formed in once through steam generators
(Elsevier, Science, Geoscience, University of Calgary, Suncor Energy, https://www.elsevier.com/journals/fuel/0016-2361/open-access-options, acceptedVersion, 2022-01-15)Extraction of hydrocarbons from oil sand deposits relies on technologies designed to lower bitumen viscosity, either by thermal energy or combination of thermal energy and solvents. Thermal energy is commonly delivered by ... -
The cisplatin/serum albumin system: A reappraisal
(Elsevier, Science, Chemistry, University of Calgary, University of Florence, University of Pisa, https://www.elsevier.com/about/policies/sharing, acceptedVersion, 2019-09-01)Since the first approval of cisplatin for cancer treatment in 1978, a lot of attempts have been carried out to characterize in detail its interactions with serum albumin, by far the most important and most abundant plasma ... -
Sample preparation of plasma enables baseline separation of iron metalloproteins by SEC-GFAAS
(Elsevier, Science, Chemistry, University of Calgary, Lumex Instruments Canada, https://www.elsevier.com/about/policies/sharing, acceptedVersion, 2020-05-03)The analysis of human plasma for biomarkers holds promise to revolutionize disease diagnosis, but is hampered by the inherent complexity of the plasma proteome. One way to overcome this problem is to analyze plasma for a ... -
Application of a Novel Metallomics Tool to Probe the Fate of Metal-Based Anticancer Drugs in Blood Plasma: potential, challenges and prospects
(Bentham, Science, Chemistry, University of Calgary, https://benthamscience.com/self-archiving-policies-main.php, acceptedVersion, 2020-06-27)Although metallodrugs are in use to treat a variety of human disorders and exhibit a remarkable diversity of therapeutic properties, they constitute only a tiny minority of all medicinal drugs that are currently on the ... -
Enamel hypoplasia and dental wear of North American late Pleistocene horses and bison: An assessment of nutritionally based extinction models
(Cambridge, Science, Biological Sciences, University of Calgary, Royal Alberta Museum, Universidad Autónoma de Zacatecas, University of Reading, https://www.cambridge.org/core/services/open-access-policies, acceptedVersion, 2019-06-03)Approximately 50,000–11,000 years ago many species around the world became extinct or were extirpated at a continental scale. The causes of the late Pleistocene extinctions have been extensively debated and continue to be ... -
Linking molecular targets of Cd in the bloodstream to organ-based adverse health effects
(Elsevier, Science, Chemistry, University of Calgary, https://www.elsevier.com/open-access, acceptedVersion, 2020-10-05)The chronic exposure of human populations to toxic metals remains a global public health concern. Although chronic Cd exposure is linked to kidney damage, osteoporosis and cancer, the underlying biomolecular mechanisms ... -
SEC hyphenated to a multielement-specific detector unravels the degradation pathway of a bimetallic anticancer complex in human plasma
(Elsevier, Science, Chemistry, University of Calgary, The City University of New York, https://www.elsevier.com/open-access/journal-embargo-finder/j, acceptedVersion, 2020-05-15)The bimetallic metal complex Titanocref exhibits relevant anticancer activity, but it is unknown if it is stable to reach target tissues intact. To gain insight, a pharmacologically relevant dose was added to human blood ... -
Toxic Metal Species and ‘Endogenous’ Metalloproteins at the Blood–Organ Interface: Analytical and Bioinorganic Aspects
(MDPI, Science, Chemistry, University of Calgary, Health Canada, https://www.mdpi.com/authors, publishedVersion, 2021-06-04)Globally, human exposure to environmental pollutants causes an estimated 9 million deaths per year and it could also be implicated in the etiology of diseases that do not appear to have a genetic origin. Accordingly, there ...