fMRI techniques to investigate the functional recovery of individual patients following ischemic stroke

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2005
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Abstract
Recently, functional magnetic resonance imaging (fMRI) has been used to investigate recovery of function post-stroke; however, it has not been implemented clinically due to the variability of measurements taken from individuals across imaging sessions. In this project, it was demonstrated that brain activity measurements based on a laterality index (LI) exhibits less variability than counting fMRI map pixels in a region of interest. It was also demonstrated that combining data from three to four runs of a specific task was required to detect <10% changes in LI across imaging sessions in individuals. Finally, T 2 * within ischemic tissue was elevated and more homogenous than in normal tissue, suggesting the need for an alternative to conventional fMRI. Overall, the results of this project provide the foundation for a clinically useful tool to investigate functional recovery of an individual patient, with the potential to impact on clinical care to help reduce long-term disability.
Description
Bibliography: p. 79-94
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Citation
Douglas, E. A. (2005). fMRI techniques to investigate the functional recovery of individual patients following ischemic stroke (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/49
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