Impact of insulin or incretin hormones in reversing diabetic neuropathy in type 1 and type 2 diabetes mellitus
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AbstractDiabetes mellitus is a metabolic disorder where long-term complications including neuropathy, or nerve damage may arise. Peripheral neuropathy affects approximately 50% of total diabetic patients. Diabetic peripheral neuropathy (DPN) is a length-dependent sensorimotor nerve disorder that can lead to pain, loss of feeling and motor ability. In this work we sought to determine whether insulin or exendin-4 will serve as neurotrophic and neuroprotective factors in both type 1 and type 2 diabetes and reverse DPN pathology. Our results showed that insulin or exendin-4 treatment improved some features of neuropathy in type 1 but not type 2 diabetes. Furthermore, a full reversal of DPN was not observed showing that current clinical dosing of insulin or exendin-4 therapy does not benefit neuropathy.
Bibliography: p. 125-138