Reciprocal regulation between voltage-gated calcium channels and calmodulin
Date
2008-06-01
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Cellscience
Abstract
Calcium entry via voltage gated calcium channels is subject to negative feedback regulation via a calcium dependent inactivation process. The features
of calcium dependent inactivation vary with calcium channel subtype and are dynamically regulated by a number of cellular processes, thus allowing
different types of calcium channels to respond differentially to local and global calcium rises. A recent study by Dick and colleagues identifies an intrinsic
mechanism by which L-type calcium channels can regulate their own sensitivity to elevation of intracellular calcium levels.
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Citation
Zamponi, G. W. (2008). Reciprocal regulation between voltage-gated calcium channels and calmodulin. Cellscience reviews, 4(4).