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dc.contributor.authorLong, Xiangyu
dc.contributor.authorBenischek, Alina
dc.contributor.authorDewey, Deborah
dc.contributor.authorLebel, Catherine A.
dc.date.accessioned2018-09-10T14:14:44Z
dc.date.available2018-09-10T14:14:44Z
dc.date.issued2017-07-15
dc.identifier.citationLong, X., Benischek, A., Dewey, D., & Lebel, C. (2017). Age-related functional brain changes in young children. NeuroImage, 155, 322–330. https://doi.org/10.1016/j.neuroimage.2017.04.059en_US
dc.identifier.issn1053-8119
dc.identifier.urihttp://hdl.handle.net/1880/107715
dc.description.abstractBrain function and structure change significantly during the toddler and preschool years. However, most studies focus on older or younger children, so the specific nature of these changes is unclear. In the present study, we analyzed 77 functional magnetic resonance imaging datasets from 44 children aged 2-6 years. We extracted measures of both local (amplitude of low frequency fluctuation and regional homogeneity) and global (eigenvector centrality mapping) activity and connectivity, and examined their relationships with age using robust linear correlation analysis and strict control for head motion. Brain areas within the default mode network and the frontoparietal network, such as the middle frontal gyrus, the inferior parietal lobule and the posterior cingulate cortex, showed increases in local and global functional features with age. Several brain areas such as the superior parietal lobule and superior temporal gyrus presented opposite development trajectories of local and global functional features, suggesting a shifting connectivity framework in early childhood. This development of functional connectivity in early childhood likely underlies major advances in cognitive abilities, including language and development of theory of mind. These findings provide important insight into the development patterns of brain function during the preschool years, and lay the foundation for future studies of altered brain development in young children with brain disorders or injury.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseries155en_US
dc.rightsUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.subjectpreschoolen_US
dc.subjectbrain developmenten_US
dc.subjectfMRIen_US
dc.titleAge-related functional brain changes in young childrenen_US
dc.typejournal articleen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.description.grantingagencyCanadian Institutes of Health Research - Project Schemeen_US
dc.identifier.grantnumberIHD-134090, MOP-136797en_US
dc.publisher.departmentPaediatricsen_US
dc.publisher.departmentRadiologyen_US
dc.publisher.institutionAlberta Children’s Hospital Research Instituteen_US
dc.publisher.institutionCommunity Health Sciencesen_US
dc.identifier.doi10.1016/j.neuroimage.2017.04.059en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33878
dc.publisher.policyhttps://www.elsevier.com/journals/neuroimage/1053-8119/guide-for-authorsen_US
dc.publisher.hasversionPre-printen_US


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Unless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
Unless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.