Objective: To evaluate the acute effects of hyperglycemia on the vasculature of lean and obese individuals. Methods: Nine normal-weight (BMI 18.1 to 24.9 kg/m2) and nine individuals with obesity (BMI 30.0 to 39.9 kg/m2) underwent five vascular occlusion tests (VOT) at baseline, 30, 60, 90 and 120 min after ingesting 75 g of glucose diluted in 296 mL of water for an oral glucose tolerance test (OGTT). Flow-mediated dilation (FMD) was determined as the percent change in brachial artery diameter from baseline (mean of the 1 min diameter recordings prior cuff release) to peak in brachial artery diameter recorded during the 3 min reperfusion period. Results: Brachial %FMD was significantly (p < 0.05) reduced at 60 min (7.98 ± 4.33 %) after glucose ingestion when compared to pre (10.9 ± 3.99 %) in the obese group. Lean individuals showed no reduction in %FMD during hyperglycemia Conclusion: Hyperglycemia caused detrimental effects on brachial artery function at 60 min after glucose ingestion.
Newton, J., Soares, R. N., & Murias, J. M. (2017). "The effects of hyperglycemia on vascular responses in individuals with obesity". 12th Annual Students' Union Undergraduate Research Symposium, November 30, 2017. University of Calgary, Calgary, AB.