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dc.contributor.advisorDuncan, Neil A.
dc.contributor.authorUrbinsky, Chris
dc.date2020-06
dc.date.accessioned2020-01-22T21:46:11Z
dc.date.available2020-01-22T21:46:11Z
dc.date.issued2020-01-21
dc.identifier.citationUrbinsky, C. (2020). Translamellar Cross-Bridge Structures of the Intervertebral Disc (Unpublished master's thesis). University of Calgary, Calgary, AB.en_US
dc.identifier.urihttp://hdl.handle.net/1880/111545
dc.description.abstractThe annulus fibrosus of the intervertebral disc is comprised of layers of circumferential lamellae. Previous studies have also identified radial structures dubbed translamellar cross-bridges, but the full extent, concentration, interconnection and their mechanical contribution, are poorly understood. The objectives of this study were to use a combination of magnetic resonance imaging (MRI) and optical coherence tomography (OCT) to document the cross-bridges in 3D and to measure the strength and stiffness of the cross-bridges using a peel test between lamellae. The images produced show an interconnected network of bridge structures throughout the annulus. The mechanical contribution proved difficult to separate from the remaining interlamellar matrix contribution, but comparing load curves between sample thicknesses, and with OCT images of the samples, did suggest discrete, radial structures influence the peel strength. This study will contribute to future tissue engineering efforts by increasing the current understanding of the native disc structure.en_US
dc.language.isoengen_US
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectntervertebral disc, annulus fibrosus, translamellar cross-bridges, magnetic resonance imaging, optical coherence tomographyen_US
dc.subject.classificationBiologyen_US
dc.subject.classificationEngineeringen_US
dc.subject.classificationEngineering--Biomedicalen_US
dc.titleTranslamellar Cross-Bridge Structures of the Intervertebral Discen_US
dc.typemaster thesisen_US
dc.publisher.facultySchulich School of Engineeringen_US
dc.publisher.institutionUniversity of Calgaryen
thesis.degree.nameMaster of Science (MSc)en_US
thesis.degree.disciplineEngineering – Biomedicalen_US
thesis.degree.grantorUniversity of Calgaryen_US
dc.contributor.committeememberDunn, Jeff F.
dc.contributor.committeememberMatyas, John Robert
ucalgary.item.requestcopytrueen_US


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University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.