The Effect of Cigarette Smoking as a Modifiable Risk Factor for Secondary Progression in Multiple Sclerosis
Date
2020-07-28
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Abstract
Objective: To investigate the influence of cigarette smoking on disease progression and disability accumulation in multiple sclerosis (MS). Methods: Kaplan-Meier analyses and Cox proportional hazard modelling were used to evaluate the influence of cigarette smoking on the time to- and age at onset of secondary progressive MS (SPMS), and on time from disease onset to Expanded Disability Status Scale (EDSS) 4.0 and 6.0 as well as the time between EDSS 4.0 to 6.0 in 763 patients with SPMS. Results: No significant associations between cigarette smoking and disease progression as measured by time to- and age at onset of SPMS, or disability accumulation, as measured by time to and age at EDSS 4.0 and 6.0 were identified. Conclusion: Our investigation of a large and well-characterized population-based SPMS cohort suggests that cigarette smoking does not influence disease progression or disability accumulation in SPMS patients.
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Keywords
Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Cigarette Smoking, Disease Progression, Disability Accumulation
Citation
Javizian, O. (2020). The Effect of Cigarette Smoking as a Modifiable Risk Factor for Secondary Progression in Multiple Sclerosis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.