The physical interaction of calcineurin with N-methyl-D-aspartate receptor subunits in rat hippocampus
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AbstractDuring long-term potentiation (LTP) and long-term depression (LTD) in the CAl region of the hippocampus, approximately 100 different proteins form a complex to modulate the jV-methyl-D-aspartate receptor (NMDA) function. The physiological significance of these protein-protein interactions in synapses from the central nervous system is unclear. One of the proteins found in the NMDA receptor complex is calcineurin, which regulates NMDA receptor channel activity. To determine the cellular events underlying calcineurin regulation of NMDA receptors, I examined the physical interaction between calcineurin and the NMDA receptor in rat hippocampus. The results show that calcineurin was found in a complex that contained NMDA receptor subunits: NRl, NR2A, and NR2B and with postsynaptic density protein-95 (PSD-95), suggesting that calcineurin physically interacts with the NMDA receptor subunits.
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