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Title: Epsin potentiates Notchpathway activity in Drosophilaand C. elegans
Authors: Tian, Xiaolin
Hansen, Dave D.
Schedl, Tim
Skeath, James B.
Keywords: Biology
Issue Date: 2004
Publisher: The Company of Biologists 2004
Citation: Xiaolin Tian, Dave Hansen, Tim Schedl and James B. Skeath "Epsin potentiates Notchpathway activity in Drosophilaand C. elegans" Development 131, 5807-5815
Abstract: pathway are known to modulate the activity of different signaling pathways. Epsins promote endocytosis and are postulated to target specific proteins for regulated endocytosis. Here, we present a functional link between the Notch pathway and epsins. We identify the Drosophila ortholog of epsin, liquid facets (lqf), as an inhibitor of cardioblast development in a genetic screen for mutants that affect heart development. We find that lqf inhibits cardioblast development and promotes the development of fusion-competent myoblasts, suggesting a model in which lqf acts on or in fusion-competent myoblasts to prevent their acquisition of the cardioblast fate. lqf and Notch exhibit essentially identical heart phenotypes, and lqf genetically interacts with the Notch pathway during multiple Notch-dependent events in Drosophila. We extended the link between the Notch pathway and epsin function to C. elegans, where the C. elegans lqf ortholog acts in the signaling cell to promote the glp-1/Notch pathway activity during germline development. Our results suggest that epsins play a specific, evolutionarily conserved role to promote Notch signaling during animal development and support the idea that they do so by targeting ligands of the Notch pathway for endocytosis.
ISSN: 0828-0584
Appears in Collections:Hansen, Dave D.

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