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Anti-Inflammatory and Cytoprotective Actions of Hydrogen Sulfide: Translation to Therapeutics

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Author
Wallace, John L.
Blackler, Rory W.
Chan, Melissa V.
Da Silva, Gabriela J.
Elsheikh, Wagdi
Flannigan, Kyle L.
Gamaniek, Iulia
Manko, Anna
Wang, Lu
Motta, Jean-Paul
Buret, Andre G.
Accessioned
2016-01-30T22:24:39Z
Available
2016-01-30T22:24:39Z
Issued
2015-04-15
Subject
Anti-Inflammatory Agents
Hydrogen Sulfide
Inflammation
Protective Agents
Wounds and Injuries
Type
journal article
Metadata
Show full item record

Abstract
Significance: There is a rapidly expanding body of evidence for important roles of hydrogen sulfide in protecting against tissue injury, reducing inflammation, and promoting repair. There is also growing evidence that H2S can be successfully exploited in drug development. Recent Advances: H2S synthesis and degradation are regulated in circumstances of inflammation and injury so as to promote repair and re-establish homeostasis. Novel H2S-releasing drugs exhibit enhanced anti-inflammatory and pro-restorative effects, while having reduced adverse effects in many tissues. Critical Issues: H2S is a pleiotropic mediator, having effects on many elements in the inflammatory cascade and promoting the resolution of inflammation and injury. It also contributes significantly to mucosal defence in the gastrointestinal tract, and in host defence against infection. There is strong evidence that novel, H2S-based therapeutics are safe and effective in animal models, and several are progressing through human trials. Future Directions: A better understanding of the physiological and pathophysiological roles of H2S continues to be restrained by the lack of simple, reliable methods for measurement of H2S synthesis, and the paucity of highly selective inhibitors of enzymes that participate in endogenous H2S synthesis. On the other hand, H2S donors show promise as therapeutics for several important indications. Antioxid. Redox Signal. 22, 398–410.
Refereed
Yes
Corporate
University of Calgary
Department
Physiology & Pharmacology
Faculty
Medicine
Institution
University of Calgary
Url
http://online.liebertpub.com/doi/abs/10.1089/ars.2014.5901
Publisher
Antioxidants & Redox Signaling
Doi
http://dx.doi.org/10.1089/ars.2014.5901
http://dx.doi.org/10.11575/PRISM/33871
Uri
http://hdl.handle.net/1880/51072
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