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Iron Oxide as an MRI Contrast Agent for Cell Tracking

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Author
Korchinski, Daniel
Taha, Mai
Yang, Runze
Nathoo, Nabeela
Dunn, Jeff F.
Accessioned
2016-03-24T15:57:39Z
Available
2016-03-24T15:57:39Z
Issued
2015-08-19
Subject
magnetic resonance imaging
iron oxide
contrast agent
cell tracking
Type
journal article
Metadata
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Abstract
Iron oxide contrast agents have been combined with magnetic resonance imaging for cell tracking. In this review, we discuss coating properties and provide an overview of ex vivo and in vivo labeling of different cell types, including stem cells, red blood cells, and monocytes/macrophages. Furthermore, we provide examples of applications of cell tracking with iron contrast agents in stroke, multiple sclerosis, cancer, arteriovenous malformations, and aortic and cerebral aneurysms. Attempts at quantifying iron oxide concentrations and other vascular properties are examined. We advise on designing studies using iron contrast agents including methods for validation.
Grantingagency
Alberta Innovates Health Solutions; National Sciences and Engineering Research Council of Canada
Refereed
Yes
Department
Radiology
Faculty
Medicine
Institution
University of Calgary
Url
http://www.la-press.com/
Publisher
Libertas Academica
Doi
http://dx.doi.org/10.4137/MRI.S23557
http://dx.doi.org/10.11575/PRISM/33512
Uri
http://hdl.handle.net/1880/51122
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