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Title: Unfolding of membrane ruffles of in situ chondrocytes under compressive loads
Authors: Herzog, Walter
Moo, Eng Kuan
Keywords: Cell and Molecular Imaging;Mechanobiology;Osteoarthritis;membrane resevoir;articular cartilage;impact loading;knee joint
Issue Date: 2016
Publisher: Journal of Orthopaedic Research
Citation: Moo, E. K., & Herzog, W. (2016). Unfolding of membrane ruffles of in situ chondrocytes under compressive loads. Journal of Orthopaedic Research.
Abstract: Impact loading results in chondrocyte death. Previous studies implicated high tensile strain rates in chondrocyte membranes as the cause of impact-induced cell deaths. However, this hypothesis relies on the untested assumption that chondrocyte membranes unfold in vivo during physiological tissue compression, but do not unfold during impact loading. Although membrane unfolding has been observed in isolated chondrocytes during osmotically induced swelling and mechanical compression, it is not known if membrane unfolding also occurs in chondrocytes embedded in their natural extracellular matrix. This study was aimed at quantifying changes in membrane morphology of in situ superficial zone chondrocytes during slow physiological cartilage compression.
Appears in Collections:Herzog, Walter

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