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Near-infrared measurements of brain oxygenation in stroke

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Author
Moreau, Francois
Yang, Runze
Nambiar, Vivek
Demchuk, Andrew M.
Dunn, Jeff F.
Accessioned
2017-03-13T21:58:34Z
Available
2017-03-13T21:58:34Z
Issued
2016-02-11
Subject
stroke
ischemic
brain imaging
near-infrared
Type
journal article
Metadata
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Abstract
We investigated the feasibility of using frequency-domain near-infrared spectroscopy (fdNIRS) to study brain oxygenation in the first few hours of stroke onset. The OxiplexTS® fdNIRS system was used in this study. Using a standard probing protocol based on surface landmarks, we measured brain tHb and StO2 in healthy volunteers, cadavers, and acute stroke patients within 9 h of stroke onset and 3 days later. We obtained measurements from 11 controls, 5 cadavers, and 5 acute stroke patients. StO2 values were significantly lower in cadavers compared to the controls and stroke patients. Each stroke patient had at least one area with reduced StO2 on the stroke side compared to the contralateral side. The evolution of tHb and StO2 at 3 days differed depending on whether a large infarct occurred. This study shows the proof of principle that quantified measurements of brain oxygenation using NIRS could be used in the hectic environment of acute stroke management. It also highlights the current technical limitations and future challenges in the development of this unique bedside monitoring tool for stroke.
Grantingagency
National Sciences and Engineering Research Council; Alberta Innovates Health Solutions
Refereed
Yes
Citation
François Moreau et al. Near-infrared measurements of brain oxygenation in stroke.Neurophoton. 3(3), 031403 (Feb 11, 2016).
Corporate
University of Calgary
Department
Medicine
Faculty
Medicine
Institution
Universite de Sherbrooke
Publisher
Society of Photo-optical Instrumentation Engineers
Doi
http://dx.doi.org/10.1117/1.NPh.3.3.031403
http://dx.doi.org/10.11575/PRISM/33521
Uri
http://hdl.handle.net/1880/51852
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