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Capillary Gas Chromatographic Separation of Carboxylic Acids Using an Acidic Water Stationary Phase

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Author
Thurbide, Kevin
Darko, Ernest
Accessioned
2017-07-27T17:10:21Z
Available
2017-07-27T17:10:21Z
Issued
2017-08-01
Subject
Gas chromatgraphy
Acidic
Water
Stationary phase
Carboxylic acids
Type
journal article
Metadata
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Abstract
An acidic water stationary phase is used for the analysis of carboxylic acids in capillary gas chromatography (GC). Under regular pH 7 operating conditions, these analytes are largely ionized and elute poorly, if at all, from the water phase. However, by adjusting the phase to pH 2, it is found that various acids are neutralized and can be readily eluted and separated in the system. Sulfamic acid is found to provide a stable pH for the water phase over time, whereas hydrochloric acid and other more volatile additives quickly evaporate from the column. Under optimal low pH conditions, the acidic analytes yield good peak shape and are readily observed for masses investigated down to 5 ng on-column. By comparison, on a conventional non-polar capillary GC column, the same analytes display threefold more peak tailing and are not detected for masses below 30 ng on-column. Through altering the phase pH, it is found that the selectivity between certain analytes can be potentially enhanced depending on their respective pKa values and/or ionizability. The analysis of various different samples containing carboxylic acids is demonstrated and the results indicate that this approach can possibly offer unique and beneficial selectivity in such determinations.
Refereed
Yes
Department
Chemistry
Faculty
Science
Institution
University of Calgary
Publisher
The final publication is available at Springer via http://dx.doi.org/10.1007/s10337-017-3333-z
Doi
http://dx.doi.org/10.11575/PRISM/30261
Uri
http://hdl.handle.net/1880/52155
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