Interactions between vibrio parahaemolyticus and human and oyster phagocytes

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dc.contributor.advisorDeVinney, Rebekah
dc.contributor.authorScott, Donna Katherine
dc.date.accessioned2017-12-18T22:33:44Z
dc.date.available2017-12-18T22:33:44Z
dc.date.issued2012
dc.descriptionBibliography: p. 82-96en
dc.descriptionSome pages are in colour.en
dc.descriptionIncludes copy of copyright permission. Original copy with original Partial Copyright Licence.en
dc.description.abstractVibrio parahaemolyticus is a Gram-negative halophilic bacterium and is the leading cause of bacterial seafood-borne gastroenteritis worldwide. V parahaemolyticus possesses two type III secretion systems (T3SS); one on each of the two chromosomes. The T3SS-I is present in all strains examined to date, whereas the T3SS-II is found primarily in toxigenic strains associated with human disease. This work examines the interaction of the bacterium in the presence of oyster hemocytes and human neutrophils in an effort to understand how the T3SSs contribute to survival in each respective niche. Various gene expression, protein secretion and phagocytosis assays were carried out with oyster hemocytes, and the overall V parahaemolyticus and neutrophil interaction was studied with bacterial and cellular viability assays. The results suggest that the T3SS-I contributes to an antiphagocytic effect in oyster hemocytes, and may mediate neutrophil cytotoxicity. Further characterization of these interactions is required to determine the mechanism behind these findings.
dc.format.extentxii, 103 leaves : ill. ; 30 cm.en
dc.identifier.citationScott, D. K. (2012). Interactions between vibrio parahaemolyticus and human and oyster phagocytes (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/4869en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/4869
dc.identifier.urihttp://hdl.handle.net/1880/105870
dc.language.isoeng
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.titleInteractions between vibrio parahaemolyticus and human and oyster phagocytes
dc.typemaster thesis
thesis.degree.disciplineMicrobiology, Immunology and Infectious Diseases
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
ucalgary.thesis.accessionTheses Collection 58.002:Box 2119 627942989
ucalgary.thesis.notesUARCen
ucalgary.thesis.uarcreleaseyen
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