Modeling a novel mechanism of calcium-induced calcium release in vascular smooth muscle cell

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dc.contributor.advisorVigmond, Edward J.
dc.contributor.advisorWelsh, Donald
dc.contributor.authorBigdely Shamloo, Kamran
dc.date.accessioned2017-12-18T22:35:40Z
dc.date.available2017-12-18T22:35:40Z
dc.date.issued2012
dc.descriptionBibliography: p. 69-72en
dc.descriptionMany pages are in colour.en
dc.descriptionIncludes copy of copyright permissions. Original copies with original Partial Copyright Licence.en
dc.description.abstractRecent work has revealed a microdomain m cerebral arterial smooth muscle comprised of caveolae and the sarcoplasmic reticulum. Immunolabeling techniques indicate that T-type Ca2+ channels (Cav3.2) and ryanodine receptors localize to this microdomain while L-type Ca2+ channels do not. Based on these observations, we hypothesize that T-type Ca2+ channels play a major role in triggering RyR receptors and consequently in modulating Ca2+ sparks. To address this hypothesis, we developed a detailed tissue-specific biophysical model that can simulate several aspects of Ca2+ sparks in cerebral arterial SMCs by integrating independent formulations of cellular components with different sets of parameter adjustments. The simulation results show that the Calcium Induced Calcium Release (CICR) process can be initiated in a virtual microdomain containing Cav3.2 and RyR channels. These CICR events are repetitive and voltage dependent in that higher depolarization lead to higher CICR frequencies.
dc.format.extentxiii, 91 leaves : ill. ; 30 cm.en
dc.identifier.citationBigdely Shamloo, K. (2012). Modeling a novel mechanism of calcium-induced calcium release in vascular smooth muscle cell (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/4963en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/4963
dc.identifier.urihttp://hdl.handle.net/1880/105964
dc.language.isoeng
dc.provenanceembargo removed as requested by author
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.titleModeling a novel mechanism of calcium-induced calcium release in vascular smooth muscle cell
dc.typemaster thesis
thesis.degree.disciplineElectrical and Computer Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
ucalgary.thesis.accessionTheses Collection 58.002:Box 2102 627942972
ucalgary.thesis.notesUARCen
ucalgary.thesis.uarcreleaseyen
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