Modeling a novel mechanism of calcium-induced calcium release in vascular smooth muscle cell
dc.contributor.advisor | Vigmond, Edward J. | |
dc.contributor.advisor | Welsh, Donald | |
dc.contributor.author | Bigdely Shamloo, Kamran | |
dc.date.accessioned | 2017-12-18T22:35:40Z | |
dc.date.available | 2017-12-18T22:35:40Z | |
dc.date.issued | 2012 | |
dc.description | Bibliography: p. 69-72 | en |
dc.description | Many pages are in colour. | en |
dc.description | Includes copy of copyright permissions. Original copies with original Partial Copyright Licence. | en |
dc.description.abstract | Recent work has revealed a microdomain m cerebral arterial smooth muscle comprised of caveolae and the sarcoplasmic reticulum. Immunolabeling techniques indicate that T-type Ca2+ channels (Cav3.2) and ryanodine receptors localize to this microdomain while L-type Ca2+ channels do not. Based on these observations, we hypothesize that T-type Ca2+ channels play a major role in triggering RyR receptors and consequently in modulating Ca2+ sparks. To address this hypothesis, we developed a detailed tissue-specific biophysical model that can simulate several aspects of Ca2+ sparks in cerebral arterial SMCs by integrating independent formulations of cellular components with different sets of parameter adjustments. The simulation results show that the Calcium Induced Calcium Release (CICR) process can be initiated in a virtual microdomain containing Cav3.2 and RyR channels. These CICR events are repetitive and voltage dependent in that higher depolarization lead to higher CICR frequencies. | |
dc.format.extent | xiii, 91 leaves : ill. ; 30 cm. | en |
dc.identifier.citation | Bigdely Shamloo, K. (2012). Modeling a novel mechanism of calcium-induced calcium release in vascular smooth muscle cell (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/4963 | en_US |
dc.identifier.doi | http://dx.doi.org/10.11575/PRISM/4963 | |
dc.identifier.uri | http://hdl.handle.net/1880/105964 | |
dc.language.iso | eng | |
dc.provenance | embargo removed as requested by author | |
dc.publisher.institution | University of Calgary | en |
dc.publisher.place | Calgary | en |
dc.rights | University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. | |
dc.title | Modeling a novel mechanism of calcium-induced calcium release in vascular smooth muscle cell | |
dc.type | master thesis | |
thesis.degree.discipline | Electrical and Computer Engineering | |
thesis.degree.grantor | University of Calgary | |
thesis.degree.name | Master of Science (MSc) | |
ucalgary.item.requestcopy | true | |
ucalgary.thesis.accession | Theses Collection 58.002:Box 2102 627942972 | |
ucalgary.thesis.notes | UARC | en |
ucalgary.thesis.uarcrelease | y | en |
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